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See also List of EDA software MACH is another general purpose EDA software from Cadence. References External links Official Website Publications Category:Electronic design automation software Category:Electronic data interchange Category:Electronic design automation companiesA New Era of Receptor-Targeted Kinase Inhibitors in the Treatment of Malignant Glioma. The epidermal growth factor receptor (EGFR) is involved in tumorigenesis, tumor progression, and maintenance of the cancer stem cell (CSC) phenotype. The CSC hypothesis of tumor maintenance has been gaining attention over the past decade and has led to the development of therapies targeting the EGFR and EGFR-related signaling pathways. Of these, the monoclonal antibodies, such as cetuximab and nimotuzumab, as well as EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, have shown efficacy in the treatment of glioblastoma multiforme (GBM), one of the most malignant types of cancer. Nevertheless, these treatments provide only temporary benefits and are ultimately ineffective due to the development of drug resistance. In this context, elucidating the mechanisms of drug resistance and targeting EGFR signaling pathways in CSCs could be beneficial for the development of novel therapies that improve treatment outcomes. Here, we summarize the mechanisms of EGFR activation and the potential targets of EGFR signaling in GBM. We describe current strategies for targeting EGFR signaling in GBM and discuss recent data on the role of EGFR signaling in CSCs.Synthesis and antimicrobial activity of new analogs of the original acid-stable beta-lactam antibiotics (1-alkyl- and 1-amino-3-alkoxy-3-aryl-2-azetidinone-1-oxides). The azetidinone oxides of 1-alkyl- and 1-amino-3-alkoxy-3-aryl-2-azetidinone-1-oxides with 2-acylaminoethyl, cyclohexylacetyl, cyclopentylacetyl and cyclopropylacetyl groups were synthesized and evaluated for their antibacterial activity. The 2-acylaminoethyl group proved to be preferable for most of the compounds, but did not exhibit satisfactory activity. Among

 

 

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